Журнал кардиореспираторных исследований 2025. №4

Тема статьи

ROLE OF OBESITY AND METABOLIC SYNDROME IN RECURRENCE OF ATRIAL FIBRILLATION (77-81)

Авторы

Nosirova D.A., Arshad Jan, Naveed Ahmed, Muhammad Toseef Mudassar, Ashknaz Javed

Учреждение

Samarkand State Medical University

Аннотация

besity and metabolic syndrome (Met syndrome) have become important and modifiable contributors to both the onset and recurrence of atrial fibrillation (AF), the most common form of sustained cardiac arrhythmia [1]. Growing evidence suggests that excessive adipose tissue particularly visceral fat plays a key role in promoting atrial structural and electrical remodeling through mechanisms involving inflammation, oxidative stress, and fibrosis. Moreover, Met syndrome, which encompasses a combination of hypertension, insulin resistance, dyslipidemia, and central obesity, further amplifies these arrhythmogenic processes. [2]. Collectively, these metabolic and structural alterations lead to atrial enlargement, disturbances in autonomic regulation, and electrophysiological abnormalities that increase susceptibility to AF initiation and persistence. Building upon these mechanistic insights, recent research has focused on how obesity and Met syndrome influence AF recurrence [3]. Clinical evidence consistently demonstrates that individuals with obesity or Met syndrome exhibit higher rates of AF recurrence, underscoring the importance of comprehensive risk factor management. Targeted interventions such as weight reduction, glycemic optimization, and aggressive control of associated comorbidities have been shown to substantially reduce recurrence risk and improve long-term rhythm stability[4,5,6].

Ключевые слова

Metabolic syndrome, insulin resistance, atrial fibrillation, dyslipidemia

Литературы

1. Kadyrova F. et al. Поширенiсть бессимптомно гiперурикемii серед хворих з iшемiчною хворобою //Здобутки клінічної і експериментальної медицини. – 2017. – №. 2. 2. Насырова З. А., Абдуллоева М. Д., Усаров Ш. А. У. СТРАТИФИКАЦИЯ ФАКТОРОВ РИСКА ПРИ ИШЕМИЧЕСКОЙ БОЛЕЗНИ СЕРДЦА //Journal of cardiorespiratory research. – 2021. – Т. 1. – №. 3. – С. 14-17. 3. Ташкенбаева Э. Н., Насырова З. А., Тоиров А. Э. Течение нестабильных вариантов стенокардии при полиморбидных состояниях //Colloquium-journal. – Голопристанський міськрайонний центр зайнятості= Голопристанский районный центр занятости, 2019. – №. 27- 3. – С. 45-49. 4. Элламонов С. Н. и др. Факторы прогрессирования артериальной гипертензии у больных в коморбидности с сахарным диабетом 2 типа //Journal of cardiorespiratory research. – 2021. – Т. 1. – №. 2. – С. 16-21. 5. Saito S, Teshima Y, Fukui A et al. Glucose fluctuations increase the incidence of atrial fibrillation in diabetic rats. Cardiovasc Res. 2014;104(1):5–14. https://doi.org/10.1093/cvr/cvu176 6. Schmitt J, Duray G, Gersh B et al. Atrial fibrillation in acute myocardial infarction: a systematic review of the incidence, clinical features and prognostic implications. Eur Heart J. 2009;30(9):1038–1045. https://doi.org/10.1093/eurheartj/ehn579 7. Schnabel RB, Yin X, Gona P et al. 50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study. Lancet. 2015;386(9989):154–162. https://doi.org/10.1016/S0140-6736(14)61774-8 8. Shanmugasundaram M, Paul T, Hashemzadeh M et al. Outcomes of percutaneous coronary intervention in atrial fibrillation patients presenting with acute myocardial infarction: analysis of nationwide inpatient sample database. Cardiovasc Revasc Med. 2020;21(7):851–854. https://doi.org/10.1016/j. carrev.2019.12.011 9. Shiga T, Wajima Z, Inoue T, et al. Magnesium prophylaxis for arrhythmias after cardiac surgery: a meta-analysis of randomized controlled trials. Am J Med. 2004;117:325–333. 10. Simmers MB, Cole BK, Ogletree ML et al. Hemodynamics associated with atrial fibrillation directly alters thrombotic potential of endothelial cells. Thromb Res. 2016;143:34–39. https://doi.org/10.1016/j. thromres.2016.04.022 11. Soliman EZ, Lopez F, O’Neal WT et al. Atrial fibrillation and risk of ST-segment–elevation versus non–ST-segment–elevation myocardial infarction: the Atherosclerosis Risk in Communities (ARIC) Study. Circulation. 2015;131(21):1843–1850. https://doi.org/10.1161/ CIRCULATIONAHA.114.014145