Журнал кардиореспираторных исследований 2025. №4

Тема статьи

DOWN SYNDROME AND CARDIOVASCULAR PATHOLOGY: CLINICAL OBSERVATION AND LITERATURE REVIEW (14-18)

Авторы

Madjidova G.T., Jumayeva S.T

Учреждение

Samarkand State Medical University

Аннотация

Complete or partial trisomy of chromosome 21 (Down syndrome) is the most common aneuploidy compatible with life, occurring in approximately 1:800 live births. Down syndrome is also the most common inherited disorder associated with congenital heart defects (CHD). At least half of all patients with Down syndrome have CHD. The average life expectancy for this disorder has increased significantly, from 25 to 53–58 years, but cardiovascular complications remain the major factor limiting the life expectancy of these patients both in childhood and later in life. In this paper, we present a clinical observation of a 59-year-old patient with Down syndrome, conduction disorders (third-degree atrioventricular block, implanted pacemaker) and severe manifestations of multisystem diseases, and also provide an overview of the spectrum and pathogenesis of cardiovascular disorders in this disease. Understanding the multisystem nature of the disease, the features of the clinical manifestations of the syndrome and timely treatment of cardiovascular pathology can significantly improve the quality of life and increase the life expectancy of these patients.

Ключевые слова

Down syndrome, congenital heart defects, mental retardation, trisomy 21, chimerism, atrioventricular septal defect, acquired cardiovascular diseases, mitral valve prolapse, aortic regurgitation, premature aging, atherosclerosis, arterial hypertension, coronary heart disease, pulmonary hypertension, arrhythmia.

Литературы

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