Журнал кардиореспираторных исследований 2025. №2/4

Тема статьи

INFLUENCE OF INTESTINAL MICROBIOTA ON THE COURSE AND OUTCOME OF OBSTRUCTIVE BRONCHITIS IN FREQUENTLY SICK CHILDREN (41-44)

Авторы

Ibragimova Marina Fedorovna, Zhamshedova Sozhida Zhamshedovna

Учреждение

Samarkand State Medical University

Аннотация

Despite the progress in antibacterial therapy and intensive care, obstructive bronchitis continues to occupy a leading position among childhood diseases worldwide. Recently, more and more attention has been paid to the role of intestinal microflora in immune regulation and its impact on the course of infections, including bronchitis. Gut microbiota is involved in the formation of both innate and acquired immunity, maintains the integrity of mucosal barriers and regulates inflammatory processes. Microflora imbalance caused by antibiotics, unhealthy diet or past infections can lead to a weakened immune response and worsen the prognosis of obstructive bronchitis. However, studies show that restoring the normal composition of microbiota alleviates the course of the disease and reduces the likelihood of complications. The study of the relationship between intestinal microflora and respiratory infections opens up new opportunities for the treatment and prevention of obstructive bronchitis in children, including the use of probiotics and microbiota correction. This work focuses on the analysis of modern data on the effect of intestinal microflora on the course and outcome of obstructive bronchitis in children. Objective: to study the effect of intestinal microflora on the course and outcome of obstructive bronchitis in frequently ill children. Materials and methods of the study. To study this problem, we conducted research in the pediatric departments of the Samarkand branch of the Republican Scientific Center for Emergency Medical Care, in the gastroenterology and pulmonology department of the Samarkand Regional Children's Multidisciplinary Medical Center. The study included 52 patients with obstructive bronchitis aged 1 to 10 years. Of these: Group I - 26 patients with obstructive bronchitis who received combination therapy with probiotics. Group II - 26 patients with obstructive bronchitis who received traditional treatment. The control group consisted of 20 practically healthy children. Conclusions. The state of the intestinal microbiota has a significant impact on the course and outcome of obstructive bronchitis in children. Dysbacteriosis can contribute to the development of inflammatory processes and a decrease in the effectiveness of the immune response. Healthy microflora helps maintain a balance between pro- and anti-inflammatory reactions, which reduces the risk of severe obstructive bronchitis and complications. Correction of microbiota with probiotics and prebiotics can improve the immune response, reduce the severity of the disease and speed up recovery. Convenient to use, higher efficiency, the absence of side and adverse effects allow us to recommend this treatment for widespread use in pediatric practice.

Ключевые слова

intestinal microbiota, obstructive bronchitis, frequently ill children.

Литературы

1. Авдеев С.Н. Интенсивная терапия в пульмонологии. М., 2015. Т. 1. 304 с. 2. Хусаинова, Ш. К. (2024). ГЕНЕОЛОГИЧЕСКИЕ ФАКТОРЫ РИСКА РАЗВИТИЯ РЕЦИДИВОВ ОБСТРУКТИВНОГО БРОНХИТА У ДЕТЕЙ. Research Focus, 3(3), 173-175. 3. Fedorovna, I. M., & Kizi, S. Z. S. (2023). STATE OF HUMORAL IMMUNITY IN PATIENTS WITH ATYPICAL PNEUMONIA IN FREQUENTLY ILL CHILDREN. Research Focus, 2(10), 125-128. 4. Хусаинова, Ш. К., Закирова, Б. И., & Махмуджанова, С. Р. (2023). THE PREVALENCE OF RECURRENCE OF OBSTRUCTIVE BRONCHITIS IN CHILDREN. ЖУРНАЛ ГЕПАТО-ГАСТРОЭНТЕРОЛОГИЧЕСКИХ ИССЛЕДОВАНИЙ, 4(3).5. Шавази Н. М., Ибрагимова М. Ф., Закирова Б. И., Лим М.В., Атаева М. С. эффективность применения препарата энтерол при диареях у детей. Журнал гепато-гастроэнтерологических исследований №1(том 2), 2021. С. 39-41. 6. Майданник В.Г., Митин Ю.В. Диагностика, лечение и профилактика воспалительных заболеваний органов дыхания у детей. ― К.: ИЦ Медпроминфо, 2006. ― 288 с. 7. Турсунова, B., Урунова, М., & Ибрагимова, М. (2023). Changes in the state of immunity at the cellular level in patients with bronchiolitis. Международный журнал научной педиатрии, 2(12), 428-430. 8. Внебольничная обструктивный бронхит у детей. Клинические рекомендации. — Москва : Оригинал-макет, 2015. — 64 с. ISBN 978-5-990-66034-2 9. Agaard K., Ma J., Ganu R., Petrosino J., Versalovic J. The placenta harbors a unique microbiome. Sci Transl Med. 2014; 6: 237-43. 10. Schroeder B., Birchenough G., Stahlman M. Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration. Cell Host Microbe. 2018; 23 (1): 27-40. 11. Fedorovna, I. M., & Ravshanovna, E. M. (2024). Optimization of treatment of atypical pneumonia due to hypoxic-ischemic encephalopathy in newborns. Research Focus, 3(1), 220-223. 12. Odamaki T., Kato K., Sugahara H., et al. Age-related changes in gut microbiota composition from newborn to centenarian: a cross- sectional study. BMC Microbiol. 2016; 16: 90-8. 13. Joly F. et al. Saccharomyces boulardii CNCM I-745. In: Marteau P., Dore J., eds. Gut Microbiota: A Full-Fledged Organ. Paris: John Libbey Eurotext; 2017: 305–350.