Биология ва тиббиёт муаммолари 2024 №1 (151)

Тема статьи



Ziyadullaev Shukhrat Hudayberdiyevich, Payzullaeva Umida Furkat kizi


Samarkand State Medical University, Republic of Uzbekistan, Samarkand


Autoimmune diseases are diseases associated with disruption of the functioning of the human immune system, which begins to recognize its own tissues as foreign and damage them. In this case, not only a specific system can be affected, but also the entire system or even the entire human body is affected. In this regard, such diseases are also called systemic. Until today, scientists have not fully identified the reason for the negative reaction of the human immune system to its own cells or tissues. Most of these diseases are chronic.Understanding of the processes occurring within the body has changed significantly due to modern technology, which has allowed us to reveal the close relationship of the intestine with the nervous, endocrine, and immune systems of the human body. It is believed that the majority of chronic diseases of multifactorial nature are based on changes in the species diversity of the intestinal microbiota, which lead to irreversible breakdowns in the homeostasis of the macroorganism. Dysfunction associated with disturbances in the qualitative and quantitative composition of the gut microbiota alters metabolic activity and promotes the development of chronic inflammation.

Ключевые слова

intestinal (gut) microbiota, autoimmune diseases, microbiocenoses.


1. Гриневич В.Б., Захарченко М. М. Современные представления о значении кишечного микробиоценоза человека. Способы коррекции его нарушений // Новые СанктПетербургские врачебные ведомости. 2003. № 3. С. 13-20. 2. Computational profiling of the gut-brain axis: microflora dysbiosis insights to neurological disor-ders / Dovrolis N., Kolios G., Spyrou G. M., Maroulakou I. // Briefings in Bioinformatics. 2017. Nov. 27. Vol. 20, Issue 3. P. 825-841. 3. The gut-brain axis: Interactions between enteric microbiota central and enteric nervous systems / M. Carabotti, A. Scirocco, M. A. Maselli, C. Severi // Ann Gastroenterol. 2015. No. 28 (2). Р. 203-209. 4. Microbiota dysbiosis controls the neuroinflammatory response after stroke / V. Singh, S. Roth, G. Llovera [et al.] // J. Neurosci. 2016. Jul 13; 36 (28): 7428-7440. 5. Lederberg J. and McCray A. ‘Ome Sweet ‘Omics - A Genealogical Treasury of Words // The Scientist. 2001. No. 15 (7). Р. 8. URL: 6. Rizaev J. A., Khaidarov N. K., Abdullaev S. Y. Current approach to the diagnosis and treatment of glossalgia (literature review) //World Bulletin of Public Health. – 2021. – Т. 4. – С. 96-98. 7. Rizaev J. A., Rizaev E. A., Akhmadaliev N. N. Current View of the Problem: A New Approach to Covid-19 Treatment //Indian Journal of Forensic Medicine & Toxicology. – 2020. – Т. 14. – №. 4. 8. Rizaev J. A., Maeda H., Khramova N. V. Plastic surgery for the defects in maxillofacial region after surgical resection of benign tumors // Annals of Cancer Research and Therapy. – 2019. – Т. 27. – №. 1. – С. 22-23. 9. Rizaev J. A. et al. Clinical and radiological characteristics of periodontic interweaves in patients with chew recessional //European Journal of Interdisciplinary Research and Development. – 2023. – Т. 11. – С. 36-41. 10. Rizaev J. A. et al. The need of patients with systemic vasculitis and coronavirus infection in the treatment of periodontal diseases //Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny). – 2022. – Т. 25. – №. 4. – С. 40-45. 11. Rizaev J. A., Kuliev O. A. Risk factors of anemia in children and prognosing of it //Электронный инновационный вестник. – 2018. – №. 4. – С. 62-65. 12. Mandal R. S., Saha S., Das S. Metagenomic surveys of gut microbiota // Genomics, Proteomics & Bioinformatics. 2015. Vol. 13, Issue 3. Р. 148-158. 13. Iannitti T., Palmieri B. Therapeutical use of probiotic formulations in clinical practice // Clin. Nutr. 2010 Dec. No. 29 (6). С. 701-725. 14. Host-gut microbiota metabolic interactions / J. K. Nicholson, E. Holmes, J. Kinross [et al.] // Science. June 2012. 336 (6086): 1262-7. 15. Оден М. Роды и эволюция Homo Sapiens (Childbirth and the evolution of Homo sapiens, 2014) / пер. с англ. М. : Изд-во Назаровых, 2016. 200 с. 16. Prostor L. M. The Human Microbiome Project in 2011 and beyond // Cell Host & Microbe. 2011. Vol. 10. Issue 4. Р. 287-291. 17. Tyakht A. V., Kostryukova E. S., Govorun V. M. Human gut microbiota community structures in urban and rural populations in Russia // Nature Communications. 2013. Vol. 4, Article number: 2469. 18. Черневская Е. А., Белобородова Н. В. Микробиота кишечника при критических состояниях (обзор) // Общая реаниматология. 2018. Т. 14. № 5. С. 96-119. 19. Qin J., Li R., Wang J. A human gut microbial gene catalogue established by metagenomic sequencing // Nature. 2010. Vol. 464. P. 59-65. 20. An obesity-associated gut microbiome with increased capacity for energy harvest / P. J. Turnbaugh, R. E. Ley, M. A. Mahowald [et al.] // Nature. 2006. Vol. 444. Р. 1027-1031.