Biomeditsina va amaliyot jurnali, 2022 №6

Тема статьи



Nadzhimitdinov U. Otabek, Usmanova J. Durdona.


Andijan State Medical Institute


Objective: to study the state of cerebral vessels in patients with chronic cerebral ischemia (CCI) on the background of type 2 diabetes mellitus (DM) and without DM. Methods: In a case-control study, 229 patients with stage I-II CCI were included. The diagnosis of CCI and its stage was established in accordance with existing criteria (Schmidt E.V., 1985; International Classification of Diseases 11th revision, 2022). Laboratory studies were performed for all patients, including fasting glucose, glycated serum hemoglobin, lipid spectrum (triglycerides, cholesterol, HDL and LDL), apoA1 and apoB. Results: Type 2 diabetes poses a higher risk of developing extracranial atherosclerotic disease than intracranial atherosclerosis, for the development of which both the duration of diabetes and the degree of its compensation are of no small importance. Conclusions. DM is an important risk factor for the development of cerebral atherosclerosis in patients with CCI. In CCI patients with type 2 diabetes, atherosclerotic changes more often affect extracranial vessels than intracranial ones.

Ключевые слова

Type 2 diabetes mellitus, chronic cerebral ischemia.


Neurology Collaborators. Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(5):459-80. 2. Ogata T., Shimada H. [Carotid Ultrasound]. Rinsho Byori. 2014;62(9):862-7. Japanese. 3. Carpenter M., Sinclair H., Kunadian V. Carotid Intima Media Thickness and Its Utility as a Predictor of Cardiovascular Disease: A Review of Evidence. Cardiol Rev. 2016;24(2):70-5. 4. Sadahiro H., Shirao S., Yoneda H., Ishihara H., Oku T., Inamura A., et al. Decreased Flow Velocity with Transcranial Color-Coded Duplex Sonography Correlates with Delayed Cerebral Ischemia due to Peripheral Vasospasm of the Middle Cerebral Artery. J Stroke Cerebrovasc Dis. 2016;25(10):2352-9. 5. Wei L.M., Zhu Y.Q., Bao Y.Q., Lu H.T., Zhang P.L., Zhao Y.W., et al. Atherosclerosis in intracranial or extracranial vessels in diabetic patients and the association with stroke subtype. Quant Imaging Med Surg. 2019;9(6):960-7. 6. Duan J.G., Chen X.Y., Lau A., Wong A., Thomas G.N., Tomlinson B., et al. Long-term risk of cardiovascular disease among type 2 diabetic patients with asymptomatic intracranial atherosclerosis: a prospective cohort study. PLoS One. 2014;9(9). e106623. 7. Abd-Allah F., Kassem H.H., Hashad A., Shamloul R.M., Zaki A. Prevalence of intracranial atherosclerosis among patients with coronary artery disease: a 1-year hospital-based study. Eur Neurol. 2014;71(5-6):326-30. 8. Zhang X.L., Fu H.J., Yang G.R., Wan G., Li D., Zhu L.X., Xie R.R., Lv Y.J., Zhang J.D., Li Y.L, et al. Beijing Communities Diabetes Study Group The effects of cardiovascular risk factor combined anti-platelet therapy and the risk of cerebrovascular events in patients with T2DM in an urban community over 96-months follow-up: The Beijing communities diabetes study 19. Diabetes Res Clin Pract. 2018;144:236–244. 9. Kirkman M.S., Mahmud H., Korytkowski M.T. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes mellitus. Endocrinol Metab Clin North Am. 2018;47:81–96. 10. Wu W., Guan Y., Xu K., Fu X.J., Lei X.F., Lei L.J., Zhang Z.Q., Cheng Y., Li Y.Q. Plasma homocysteine levels predict the risk of acute cerebral infarction in patients with carotid artery lesions. Mol Neurobiol. 2016;53:2510–2517. 11. Fayfman M., Pasquel F.J., Umpierrez G.E. Management of hyperglycemic crises: Diabetic ketoacidosis and hyperglycemic hyperosmolar state. Med Clin North Am. 2017;101:587–606. 12. Olamoyegun M., Ibraheem W., Iwuala S., Audu M., Kolawole B. Burden and pattern of micro vascular complications in type 2 diabetes in a tertiary health institution in Nigeria. Afr Health Sci. 2015;15:1136–1141. 13. American Diabetes Association: 8. Pharmacologic approaches to glycemic treatment: Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018;41(Suppl. 1).: Р. 73–85. 14. Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, Biller J, Brown M, Demaerschalk BM, Hoh B, et al. American Heart Association Stroke Council 2018 guidelines for the early management of patients with acute ischemic stroke: A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2018;49:e46–e