Kardiorespirator tadqiqotlar jurnali. Maxsus son. 2022

Тема статьи



Nabieva D.A.,, Tashpulatova M.M.


Tashkent Medical Academy


Objective: To optimize the methods of the basic treatment of early rheumatoid arthritis (RA).years. By random assignment, patients were randomized into three groups: 1st group monotherapy with methotrexate (MTX) 10-20 mg / week (MTX; n = 40); 2nd group – MTX combined with small doses of glucocorticosteroids (GC) prednisolone in a dose of 10 mg per day orally (MTX + GC; n = 30); 3rd group - monotherapy with leflunomide (LF) 20 mg / day (LF; n = 20). Patients were allowed to continue taking nonsteroidal anti-inflammatory drugs (NSAIDs) in the previous doses, as well as external using of antiinflammatory drugs, exercise therapy, physiotherapy and occupational therapy if demanded,. If necessary, conducted intra-articular GC, but no more than 1 per in 1 month using 1 ml diprospan per administration. All patients before treatment and during follow-held standart clinical, laboratory and instrumental examination. Total activity of disease assessed by DAS28 index which recommended by the EULAR with the release of the 4 major powers. Results: The positive dynamics of the basic clinical and laboratory manifestations of early RA under the influence of all analyzed therapeutic options was evident. Thus a significant reduction of disease activity as compared to baseline was maintained at 3, 6 and 12 months of treatment. This represents a significant and long-term therapeutic effect as monotherapy LF and MTX as well as combination MTX with GC. Conclusion: All the studied variants of therapy in patients with early RA have demonstrated a significant efficacy and a very reasonable safety. Therefore, each of the schemes can be used to treat these patients with a high probability of achieving a significant improvement. Keywords: early rheumatoid arthritis, combination therapy, the basic anti-inflammatory drugs

Ключевые слова

early rheumatoid arthritis, combination therapy, the basic anti-inflammatory drugs


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